Pneumatic fluorine-lined diaphragm valve, which consists of a pneumatic actuator and a fluorine-lined diaphragm valve. The small film actuator or piston fluorine-lined actuator is adopted, and the small film actuator is 30% less in height and weight than the old actuator; The inner wall of the cylinder of the piston fluorine-lined actuator is equipped with a fluorine-lined layer, which has a smooth surface and strong sealing, so the actuator has a large thrust and is economical and applicable. Since the inner cavity and diaphragm liner of the diaphragm valve are lined and components made of corrosion-resistant fluoroplastic (FEP, PFA), the inner cavity of the valve and the diaphragm can achieve the same corrosion resistance. The valve has a simple flow path, no stuffing box, and has the advantages of low resistance and large flow coefficient. It is suitable for cutting and adjusting strong corrosion, high viscosity, particles, fibers and toxic media. It is widely used in automation devices in petrochemical, electric power, metallurgy, papermaking and other industrial sectors.